The discovery and development of angiotensin II antagonists.
نویسندگان
چکیده
4. 3.1. 3.2. 3.3. 3.4. The Renin Angiotensin System (RAS) . . . . . . . . . . . . . . . . . . . . . . . . . . In Vitro Assays . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Renin Inhibitor Design . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Novel Transition-State Analogues . . . . . . . . . . . . . . . . . . . . . . . . . . Models to Evaluate Pharmacological Responses . . . . . . . . . . . . . . . Molecular Weight, Proteolytic Stability, and Aqueous Solubility . . Renin Inhibitors with Oral Bioavailability . . . . . . . . . . . . . . . . . . . . Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
منابع مشابه
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عنوان ژورنال:
- Pharmaceutical biotechnology
دوره 11 شماره
صفحات -
تاریخ انتشار 1998